Lincoln Burrows is on death row for the murder of the vice presidents brother. He insists hes innocent and only his brother Michael Scofield believes him. As an engineer who helped design the prison where Lincoln is being held, Michael takes drastic measures to help his brother. He gets himself arrested and sent to the same prison so that with his knowledge of the building the two of them can escape together. However, while inside, Michael discovers a massive conspiracy that is determined to see Lincolns sentence carried out. Breaking out will be more difficult than he thought, but hes still going to try...